2-BE itself is not commercially produced in Canada. For this reason, some items on this page will be unavailable. Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. Symptoms may include tiredness, … NIH 11.1. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. This assessment summarizes available information on I. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, ... 2 Japan Industrial Safety and Health Association. It can harm the eyes, skin, kidneys, and blood. Summary: 2-Butoxyethanol is a clear colorless liquid that smells like ether. : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … Ethylene … J Occup Health. (USCG, 1999) DIPROPYLENE GLYCOL BUTYL ETHER can be found in 39 products. Pubmed Abstract USA.gov. 3 Independent Consultant. Substance Name — Ethylene glycol monobutyl ether (EGBE) CASRN — 111-76-2 Last Revised — 3/31/2010 . Arch Toxicol. 4.3. Stability No data submitted 3.2. NIOSH Criteria for a Recommended Standard. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 4 Fukushima Medical University. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. Ingestion or skin contact causes headache, nausea, vomiting, dizziness. This database provides human health benchmarks for pesticides that may be present in drinking water. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC) ... compared to other product formulations. ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). Final report on the safety assessment of Triethylene Glycol and PEG-4. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE For Synthesis Safety Data Sheet www.lobachemie.com 03/06/2016 3/8 4.2. 2-Butoxyethanol is a clear colorless liquid that smells like ether. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. HHS Ethylene glycol monobutyl ether has also been tested for teratogenldty … Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Another group of 121 lamination workers with indirect exposure to EGME was recruited as the control group. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Br J Ind Med. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. This can cause anemia. 1977 May 26;267(5609):335 US NIOSH Target Organs & Routes of Entry Respiratory Effects: Inhaled ethylene glycol can irritate the respiratory tract. by Alicia Minns, MD. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. J Occup Health. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. The level of exposure depends upon the dose, duration, and work being done. The acute and subehronic toxicity of EGEE, EGPE and EGBE was reviewed by C. C. Conaway (Texaco, 1994;66(4):249-54. doi: 10.1007/BF00454363. 1. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Symptoms/effects after skin contact : Harmful in contact with skin. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. This substance ranges from B to C depending on concentration/usage. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. FIRST AID MEASURES First aid measures Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. DEG is a widely used solvent. 2-BE … Initial adverse health effects caused by ethylene glycol intoxication include central nervous system depression, intoxication, euphoria, stupor, and respiratory depression. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. Ethylene Glycol Monoethyl Ether (110-80-5) LD50 oral rat 1746 mg/kg LD50 dermal rabbit … It is miscible in water, alcohol, ether, acetone, and ethylene glycol… Reregistration Branch 1 Health Effects … 2-Butoxyethanol acetate is a colorless liquid with a fruity odor. Flammable and/or toxic … Miller RR, Hermann EA, Young JT, Landry TD, Calhoun LL. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). ETHYLENE GLYCOL ETHERS PANEL TO REMOVE ETHYLENE GLYCOL MONOBUTYL ETHER FROM THE TOXICS RELEASE INVENTORY UNDER SECTION 313 OF THE EMERGENCY PLANNING AND COMMUNITY RIGHT-TO-KNOW ACT OF 1986 Jonathon Busch Director, Ethylene Glycol … In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. 1984 Aug;57:165-75. doi: 10.1289/ehp.8457165. Environmental Health Perspectives Vol. Fast, free, expert help 24×7×365 1‑800‑222‑1222. Throat and upper respiratory irritation were the most common complaints following prolonged experimental exposures in humans (4 weeks at concentrations of 1-25 ppm). 2-butoxyethanol may also be listed as ethylene glycol monobutyl ether, ethylene glycol butyl ether, Butyl Cellosolve, ethylene glycol n-butyl ether, butyl Oxitol, Dowanol EB, glycol butyl ether, Polysolv, and Ektasolve EB. 1987 Nov;91(2):222-34. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. ETHYLENE OXIDE Causes reproductive effects . 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. Epub 2017 Jun 26. Note: Javascript is disabled or is not supported by your browser. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. 1. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Google Scholar Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. Animal studies have reported reproductive and developmental risks from inhalation … Information on toxicological effects . -, Toxicol Appl Pharmacol. 1979 Jan;21(1):29-35 Chemical Name. Print Share on: Evidence. In the first study, a group of two men and six rats were exposed simultaneously for 4 hours to an EGBE concentration of 113 ppm in a 1,250 cubic ft room. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. Nausea and … Environ Health Perspect. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… ICSC Routes of Exposure and Symptoms. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds. Environ Health Perspect. Office of Pesticide Programs Pesticide Chemical Search. REACH regulation aims to improve the protection of human health and the environment from the risks that can be ... new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects ... 2-butoxyethanol ethylene glycol monobutyl ether butyl cellosolve . " DISCLAIMER: The ILO does not take responsibility for content presented on this web portal that is presented in any language other than English, which is the language used for the initial production and peer-review of original content. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. In this document, NIOSH recommends occupational exposure limits for ethylene glycol monobutyl ether (EGBE) and its acetate, ethylene glycol monobutyl ether acetate (EGBEA). ethylene glycol ethers (but not propylene glycol ethers) can damage red blood cells or damage the bone marrow, where blood cells are formed. FIRST AID MEASURES First aid measures Eye contact Rinse … 0.03ppm; P=0.017). It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. 2-BE itself is not commercially produced in Canada. Effects observed in humans included nasal and … 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. 1984 Aug;57:75-84. doi: 10.1289/ehp.845775. Consult a physician. 1974 Feb;27(2):342-54 Health Hazard Assessments for Noncarcinogenic Effects . Diethylene Glycol Poisoning I.A. Some chromatograms showed that subjects were co-exposed to m-xylene, ethylene glycol monomethyl ether, and ethylene glycol monoethyl ether acetate. CAS-Number. Aspects of biological monitoring of exposure to glycol ethers. -. 2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484 Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Where is it found and how is it used? Environ Health Perspect. some . Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate … Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release Reporting, 60818-60825 [2015-25674] Find Lowest Prices. Cohen, R. (1984) Reversible subacute ethylene glycol monomethyl ether toxicity associated with microfilm production, a … (ethylene glycol monobutyl ether) [CAS No. EPA/635/R-08/006F. Int Arch Occup Environ Health. In humans, 100 ppm (69 mg/kg bw/day) resulted in ocular and respiratory Irritation, altered taste and nausea (Carpenter et al., 1956). 57, pp. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol… The RfD is an estimate (with uncertainty … Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects… Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. On the other hand, ethylene glycol, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monoacetate or ethylene glycol diacetate showed no such an effect. Information available on … The ether being relatively unreactive. NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … Where is it found and how is it used? Substance name : Glycol Ether EB CAS-No. Likely routes of exposure : Inhalation; Skin and eye contact . 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol… Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. Precautions. Cincinnati, OH, US Department of Health and Human Services, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 1990. 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